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Our View of Migraine Disease

Where Migraine and trigeminal neuralgia end with our novel treatment



Our approach to treating and managing migraine headaches yielded gratifying results that have encouraged us to reevaluate scientific literature and our products. Simultaneous treatment of trigeminal and occipital nerves has never been approached. Migraine headaches and craniofacial neuralgia in 90% of cases involve both trigeminal and greater occipital nerves. Treatment of one nerve without simultaneous treatment of the other did not prove helpful in any of our patients. However, concurrent treatment of mentioned nerves resulted in the longest discontinuation of migraine headaches.

The interaction of genetic signaling with cell surface receptors is a new subject in molecular biochemistry and biology. Recent studies hypothesized that the genetic signals are silencing and de-silencing within the autonomic nervous system. Per se balancing the stimulatory effect of the perivascular sympathetic and parasympathetic. This effect is possibly induced by expressive genetic inhibition of cyclooxygenase-2(COX-2) and nearly all pro-inflammatory cytokine genes. However, laboratory research studies on animal models revealed that the neural, vascular supply and its control by autonomic nerves play a crucial role in the bio-mechanisms of the cell anoxia and hypoxia and the neuro-inflammatory mechanism of the peripheral nerve cells. Thus, various external signals in the physical environment may cause the original primary sympathetic gene hyper-expression that silences parasympathetic progression and regulatory genes in the peripheral vasa nervorum.

Migraine headaches are episodic neurovascular disorders characterized by recurrent unilateral headaches. Associated symptoms are nausea, vomiting, photophobia, phonophobia, conjunctival injection, lacrimation, loss of speech, temporal-mandibular joint, and dental pain. However, the pain is bilateral, and a person feels only the strongest one first. Current popular theories suggest that the initiation of a migraine attack is primarily a neuropeptides cascade event in the central nervous system. probably involving a combination of genetic changes in ion channels and environmental changes, which render the individual more sensitive to environmental factors; this may, in turn, result in a wave of cortical spreading when the attack is initiated. (General common hypothesis). Another view suggests a genetic etiology of migraine headaches based on the physical environmental trigger at an exceedingly early stage. Usually, the presence of a family history demonstrating the same hereditary habit in the system. Some researchers speculate that genetically, migraines are a complex familial disorder in which the severity and the susceptibility of individuals are most likely governed by several genes that vary between families. This hypothesis erratically believes that migraine is a lifetime disease with no cure for it. We do not follow this view. We cure migraines and witness for years the happiness of our patients.

How do humans and mammals defend their life against the physical world?

Primarily, sympathetic and parasympathetic nervous systems are genetically designed as an initial primitive internal defense mechanism. It is universal to almost all species on the planet of earth. Its mechanism and pattern may differ on the surface and in the water, environment living species. The autonomous nervous system is an internal alert system communicating with our physical world. The presence of the physical world is subject to programming our brain centers. The plasticity and highly fragile human body system are defenseless against physics laws such as gravity and weight, wavelength and visible and invisible lights, velocity, pressure, and acceleration. The question arises of how the warning system inside us works. There is a warning system with its signals embedded in our whole system as human beings or mammals. The fundamental defense mechanism in almost all species is the same. A warning signal is pronounced mainly through pain or other unpleasant symptoms such as nausea, vomiting, diarrhea, spasm of the airways and throat, and visual loss, depending on its location. Warning signals modified by molecular receptors of five somatosensory systems:

  1. Gustatory system (taste),
  2. Olfactory system (smell),
  3. Vestibulo-Auditory system (balance/hearing),
  4. The Visual system, and
  5. Somatosensory, tactile systems (touch),

These are managed by higher sophisticated regulatory brain centers. Navigation of animal life for survival in response to a physical environment controlled by one and each of the somatosensory organs as a first-line defense mechanism. However, later in the process of evolution, the emotional, sensory system developed from communication in the path of civilization. Therefore, the power of emotional sense is genetically imbedded in the civilized animal’s brain and behavior. The Limbic system is responsible for the awareness threshold and is our major vibrant center. It receives input from all somatosensory organs and analyses the data to determine how safe the physical and emotional environment we are entering is. Emotional sense modifies the concept of an internal stressor as a modifier of the sympathetic signals in a self-defense approach.

Factors such as bright lights and ultraviolet waves, flickering lights, invisible cosmic rays, as well as specific visual patterns, smells, noises, tastes, may trigger migraines. Lifestyle stressors may also trigger migraine attacks. It has been hypothesized that visual cortical hyperexcitability can be responsible for migraine—all mammals’ organ systems serving the brain as an ultimate creator of life. Brain programmed through its sensory organs few inches far from it. In controversy to a computer, it needs more time to be programmed and connected. Whenever it is programmed changes the world beyond programmed capacity.

In his testimony, Nicola Tesla stated once,” When a child is born, its sense-organs are brought in contact with the outer world. The waves of sound, heat, and light beat upon its feeble body, its sensitive nerve-fibers quiver, the muscles contract and relax in obedience: a gasp, a breath, and in this act a marvelous little engine, of inconceivable delicacy and complexity of construction, unlike any on earth, is hitched to the wheel-work of the universe. The little engine labors and grows, performs more and more involved operations, becomes sensitive to ever subtler influences, and now there manifests itself in the fully developed being – Man – a desire mysterious, inscrutable and irresistible: to imitate nature, to create, to work himself the wonders he perceives.”

Migraine is a common and potentially severe chronic, disabling disease present in all species and races. The prevalence of migraines in the U.S. adult population is roughly 80% among women and 20% among men. This equates to approximately 30 million American adults who suffer from migraine headaches. Data shows that more than 75% of patients report one to 14 headaches per month. Over half of these attacks produce severe impairment, forcing the individual to bed rest. Estimates range as high as 112 million bedridden days per year, translating into reduced productivity with the likelihood of missing work, planned events, and interfering with daily activities. The financial burden on patients and businesses is immense, with the cost to employers calculated to be $14 billion annually. (Cephalgia)

It is helpful for primary health care professionals to understand and treat migraines as a potentially burdensome and chronic neurological disease. Yet, ironically, epidemiological studies show that about 50% of patients seeking medical consultation for migraines are not being diagnosed, regardless of the reported impact and severity of the disorder.

Do children suffer from migraines? Yes. Data from the U.S.-“Migraine research foundation” show that: – about 10% of school-age children suffer from migraine – half of all migraine sufferers have their first attack before the age of 12 – the prognosis for children with migraine is variable. However, 60% of sufferers who had adolescent-onset migraines report ongoing migraines after age 30. The forecast for boys tends to be better than for girls” (Migraine in Children).

Data shows that half of all migraine sufferers have their first attack before the age of 11. However, migraine is seen in children as early as 6. Before puberty, boys experience more than the girls their Migraine Headaches, however with grown age out of puberty, the pattern changes for girls. 50%-60% of children with migraine headaches present ongoing migraines of different quality and intensity in their later generations. Variety of Migraine type described in the literature. The essential migraine in children is:

  • Migraine without aura
  • Migraine with aura
  • Hemiplegic migraine

Chronic migraine, in general, is accompanied by complications such as persistent aura, associated with nausea and vomiting, seizure-type activities, and recurrent abdominal tenderness/cramps often called abdominal migraine. Chronic migraine and episodic often causing benign paroxysmal (sporadic) vertigo, torticollis (stiffness of neck), and a feeling of numbness and tingle in the extremities. The feature of migraines in adults and children are almost the same. The only difference is the level of pain tolerance and conscious handling of the events.

Because of the severity and traumatic experience of migraine headaches, many parents are forced to homeschooling their children. Children are then deprived of their normal youthful daily activities at school. The trauma continues into chronic anxiety and depressive disorder for parents and children at the same time. Research demonstrates that these children have gone through any diagnostic tests and treatment modalities without resolution of their symptoms. Some desperate parents even accept willingly provide cannabis and other illicit drugs to their children with the hope to help.

Let us help your children’s migraine Headaches. Our treatment is innovative and tolerable for children aged ten and older.

Our treatment provides in over 95% of patients with only one session treatment a significant resolution. There is no need for necessary medication for the continuation of care. Children with our treatment may have more chance to return to everyday school life without debilitating headaches than the children on abortive and preventive medications.

The pattern of disorder consequently demonstrates depression, anxiety, generalized phobias, and other nonspecific mood disorders that may add to an individual’s disease during the period of chronicity of migraine headaches.

With the broad range of manifestations, the dynamic of migraine attacks gave rise to plenty of scientific and nonscientific cause theories and hypotheses. It is important to note that most of them have yet to be scientifically proven. To understand our empiric treatment and satisfactory long-term results, I was determined to reevaluate the theories, hypotheses, and laboratory research results from involved medical investigators within Migraine headache literature. I made an outright effort for my research to be objective and critical.

The sympathetic and parasympathetic nervous systems in all vertebrates acting almost similarly. The peripheral and central nervous systems are influenced to a higher degree by autonomous nerves by controlling their blood supply. Blood supply is imperative for the normal function of the nerve cell. One hundred percent Oxygen is required for the proper survival and functionality of the nerve cells. Therefore, the autonomous nervous system plays a crucial role in delivering Oxygen to the Central Nerve System and peripheral nerves. A profound understanding of this system provides a closer insight into the trigeminal and occipital neuralgia in our understanding of migraines.

The autonomous nerve system is an independent, genetically self-managed, and self-controlled system that serves a complex multifunctional internal system of organs. Its warning system is exhibited by producing a cascade of toxic agents called ‘cytokines/Cytotoxins,” which we feel due to pain. Pain is a warning system, which materializes the dangerous environmental condition in our consciousness. Its function continues even when the cerebral cognitive centers are out of operation. The autonomous nerve system demonstrates the dual tasks of pro and contra functioning systems called sympathetic and parasympathetic “nervous systems.” Their activities may affect human and animal emotions and vice versa.

The diffuse and broad bands network of sympathetic and parasympathetic nerve fibers, therefore, make it impossible for surgeons to have a complete and successful sympathectomy or even neurectomy. The painful malfunctions return after a period. Reflecting the complexity of understanding and decoding the interconnections of “rami Communicants” seems highly challenging for neurosurgeons in their sympathectomy efforts.

The sympathetic and parasympathetic nervous systems are highly functional independent systems that naturally balance one another. Physiologically, there are switching systems and signals that genetically determine the silencing or de-silencing of the sympathetic and parasympathetic action. For example, nerves innervating the dilator pupillary muscle are sympathetic, and nerves innervating the pupillary sphincter muscle are parasympathetic.

Migraine headache seems to demonstrate a disbalance between sympathetic and parasympathetic innervations of the brain-vascular system rather than only a central cortical cause. However, the synthesis of neurotoxins in the brain per se does not cause Brain-Pain. Naturally, the brain does not exhibit pain receptors—synthesis of intracerebral neurotoxins affecting functionally different physiologic paths in the brain centers, e.g., in stroke. Instead, there seems to be a chronic periodic vasoconstrictive impulse release in the parasympathetic ganglia and the associated sympathetic peripheral nerves, which are predilections to anoxia/hypoxia by vasoconstriction. Vasodilation does not exhibit acute inflammatory reactions, consequently, synthesis of cytokines—the viability of brain cells and peripheral nerve although it depends on blood circulation. Mechanism of blood flow control, such as autoregulation, depends on nitric nerves, which play a crucial role as neurotransmitters in vasodilating cerebral and peripheral nerve arteries in mammals. Endogenous nitric oxide released from the nerve innervating cerebral arteries by vasa Vasorum contributes to the maintenance of blood flow in major cerebral arteries necessary to supply blood to different brain centers and peripheral nerves. Recent molecular biologic research demonstrates the role of critical signals and biological switches. An alteration of the balance between excitation and inhibition gained transition of conductance by fundamental alerts triggered when the physical environment closely affects any somatosensory systems. In response, the defense mechanism activates by turning the switch toward a flight to distance from the trigger influence. Pain per se is the initial infuriating signal to acknowledge negative physical energy toward the sensory organs. Whenever the same hazardous stimulus approaches the sensory system afterward the initial attack, the system is alerted of the negative energy, even though sometimes the individual is no more sensitive to that stimulus. A biofeedback mechanism between the memory system and periphery playing a role.

The severity of pain or other symptoms such as hyper-salivation, dizziness, nausea/vomiting, numbness/tingling, ophthalmoplegia (pain in the eyes), dysarthria (loss of speech), etc., depends on the duration of negative physical force-activity and the individual’s reaction to it. For instance, exposure to fluorescent light and certain rays of sunlight may destroy ganglia cells of the retina. Extremely rapid ciliary constriction would reduce the level of the damaging light input to the retina, and spasms of the eyelids complete the blockage of the light from further destructive action on the retina. However, initiated vasospasm within milliseconds releases cytotoxins simultaneously, translating the whole process into acknowledgeable pain for an individual. We understand that the new technology of Computer and TV screens have its unique industrial wavelength, high intensity, and intolerance at the level of human retinal receptor ganglions. It may affect the human eye and brain adversely in a destructive and modifying manner within decades, even centuries. A transition of balanced key signals toward sympathetic key signals by industrial phototoxicity may happen in the future.

Data obtained from molecular biologic studies revealed that prolonged or high-intensity exposure to visible or invisible light leads to photoreceptor cell death called “APOPTOSIS.” In recent years, the problem of phototoxicity has become a focus of interest in the research study of eye and skin diseases related to computerized lifestyle.

Why the Headache Clinic?

Our treatment is based on our understanding and knowledge of migraine headaches. The treatment plan includes a one-session treatment with rewarding results. The therapy starts with a preliminary evaluation of the patient’s medical records, medications, history, and particular pain behavior. Patients with classical trigeminal neuralgia and Occipital neuralgia are selected after being educated about the treatment. Will discontinue all drugs taken for migraines will at the time of consultation. Before treatment, individuals will return to the clinic for necessary tests such as MRI of the brain, CTCB of the Jaws (if any required). All patients may provide an MRI or C.T. scan of the brain and CTCB-panoramic imaging of the Jaw to precisely evaluate the cause.

After the initial treatment, patients will return if any symptoms of pain continue or recur. They will immediately receive the treatment for the additionally affected nerve branches, which may take over one hour. We request that patients temporarily halt medications such as Plavix, Coumadin, aspirin, fish oil, and vitamin E a few days before the treatment to avoid bruises and bleeding.

We utilize a mixture of powerful injectable medications into the branches of the trigeminal and occipital nerves. The compound is administered meticulously in minimal portions of 0.1-0.3 ml using a thin needle. (Patent). No premedication or intravenous access is necessary. There is no downtime involved with the treatment, and patients may return to daily activities the very same day. Medications used in our protocol and formula are very potent and in minimal dosage. However, combined or singled administrations of those medications are known to the headache’s clinics and research literature with no success. Our formula is a novel combination based on science and 21 years of research—discovering our novel understanding and algorithm with promising results of our knowledge. We did think out of the box and gone the hard way.

The key mechanism in our treatment is turning sympathetic signals and switch toward the primary balance by silencing the frail sympathetic vasoconstrictive effect. The main contribution of our treatment is to address all trigeminal nerve branches accessible without harming our patients. Our attention to pterygopalatine ganglion bilaterally increases the success rate in very resistant cases. The combination formula of Cure Migraine medication investigated in our clinic for years, in certain proportion serving this purpose rewardingly. We utilize a treatment based on years of experience and a broad neurological, molecular biological knowledge of 21st-century research and expertise. We believe strongly that headaches pain is a peripheral phenomenon serving brain safety and functionality. We are courageous to say we changed the past dogma. We do not limit our knowledge to past hypotheses and expected standards of migraine treatment.

Over 95% of our patients received only one treatment session eliminating their Migraine and Facial pain. The rest may return for a partial or limited touch-up to undetected diseased nerve branches. Cure Migraine treatment is in principle noninvasive, less expensive, and less traumatic than Onabotulinum Toxin A, Cannabis, Anti-seizure medications, Triptans, Ketamine drips, monoclonal antibodies, and surgical, implantable procedures to children and adults. It eliminates frequent Emergency department visits and hospitalizations.

  • Is your child going through a traumatic daily Migraine headache?
  • Is your child already taking several anti-seizure medications and abortive pills or injections without resolution?
  • Did you allow her/him to use non-sense cannabis?
  • Is your child already missing school and playful days of the school?
  • Is your child already on a homeschooling program?
  • Did you experience failure of frequent Botox treatment for your child?
  • Do you want to see your child blooming happily and make changes in your and their life?

Then ask us for help. Visit us at www.curemigraineworldwidellc.com.